Small intestine & ampulla
Inflammatory disorders
Diaphragm disease
Author: Nat Pernick, M.D.
Last author update: 1 August 2012
Last staff update: 18 November 2020
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Diaphragm disease[TIAB] small bowel
Table of Contents
Definition / general | Case reports | Treatment | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Pernick N. Diaphragm disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallboweldiaphragmdisease.html. Accessed November 29th, 2024.
Definition / general
- Small bowel pathology related to NSAID use, first described in 1988 (J Clin Pathol 1988;41:516)
Case reports
- 46 year old woman with chronic aspirin use (Case of the Week #240)
Treatment
- Cessation of NSAID use
- Often surgery (Colorectal Dis 2012;14:804) or endoscopic balloon dilation (Gastrointest Endosc 2006;64:1014)
Gross description
- Segmentation of ileum by incomplete mucosal diaphragms, defined as thin circumferential membranes resembling the plica circularis, composed of mucosa and submucosa with accompanying fibrosis
- Also ulceration, strictures, perforation
Gross images
Case #240
Various images
Images hosted on other servers:
Various images
Microscopic (histologic) description
- Thin circumferential membranes resembling plica circularis, composed of mucosa and submucosa with accompanying fibrosis
- Neuromuscular and vascular hamartoma-like changes, eosinophilic enteritis and acute inflammation (Am J Clin Pathol 2008;130:518)
Microscopic (histologic) images
Case #240
H&E
Trichrome
Differential diagnosis
- Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE): small intestinal strictures and ulcerations of unknown origin (World J Gastroenterol 2011;17:2873), characterized as atypical vasculitis presenting with unexplained stricture and ulceration of the small bowel in young and middle aged patients but without systemic inflammation; treated with steroids
