Small bowel (small intestine)
Benign tumors and tumor-like conditions
Common variable immunodeficiency syndrome

Authors: Hanni Gulwani, M.D. (see Authors page)

Revised: 24 August 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: common variable immunodeficiency syndrome
Cite this page: Common variable immunodeficiency syndrome. website. Accessed January 19th, 2018.
Definition / general
  • Primary immune defect (usually genetic) causing reduction in B cells and most immunoglobulin classes; also frequent bacterial infections (eMedicine)
Clinical features
  • Chronic diarrhea, malabsorption, recurrent GI giardiasis
Case reports
Microscopic (histologic) description
  • Mucosa may resemble celiac sprue or be normal, but always has reduced plasma cells and no IgA plasma cells
  • May have lymphoid hyperplasia or apoptotic bodies in crypts
  • Histologic patterns: lymphocytic colitis, collagenous enterocolitis, celiac disease, granulomatous disease, acute GVHD and IBD (Am J Surg Pathol 2007;31:1800)
Microscopic (histologic) images

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Case of the Week #398:

H&E images