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Small bowel (small intestine)


Collagenous sprue

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 13 November 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Subtype of refractory sprue with patchy, excessive subepithelial collagen deposits (5 of 10 patients in one study, Am J Surg Pathol 2000;24:676)
● May eventually respond to gluten-free diet (Mod Pathol 2010;23:12), but disease may also be fatal

Micro description

● Small intestinal villous and crypt atrophy, subepithelial collagen deposit thicker than 12 Ám that entraps lamina propria cellular elements (Arch Pathol Lab Med 2011;135:803)

Micro images

Various images

End of Small bowel (small intestine) > Malabsorption > Collagenous sprue

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