White sponge nevus
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Revised: 5 July 2009, last major update November 2008
Copyright: (c) 2005-2009, PathologyOutlines.com, Inc.
● Rare, typically autosomal dominant disorder due to mutation in mucosal keratins CK4 () and CK13 (J Dent Res 2001;80:919)
● Primarily affects nonkeratinized stratified squamous epithelium
● First described by Cannon in 1935 (Arch Dermatol Syphilol 1935;31:365)
Treatment and prognosis
● No standard treatment
● Possibly tetracycline
● Progression usually stops at puberty
● No malignant transformation
● White to gray, diffuse, painless, spongy and folded plaques on buccal mucosa
White plaques on buccal mucosa White plaques on tongue
● Parakeratosis, acanthosis with formation of large blunt rete ridges, spongiosis
● Extensive vacuolation of suprabasal keratinocytes
● Dyskeratotic cells exhibit dense peri- and paranuclear eosinophilic condensations, which correspond to tonofilament aggregates
● Abundant Odland bodies (keratinosome, membrane bound granule in upper stratum spinosum) within keratinocytes, but few are present in the intercellular spaces
Parakeratosis, acanthosis and spongiosis of mucosal epithelium with blunting of rete ridges; vacuolated and dyskeratotic epithelial keratinocytes demonstrate perinuclear eosinophilic condensations
End of Skin-Melanocytic Tumors > White sponge nevus
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