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Skin-Melanocytic tumors
Speckled lentiginous nevus
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Revised: 7 July 2009, last major update June 2009
Definition
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● Relatively common cutaneous lesion characterized by multiple darkly spotted light-brown macules or papules within a pigmented patch
● Congenital (Arch Dermatol 2001;137:172) or acquired
● Slight potential to develop into melanoma
Terminology
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● Also known as Nevus spilus
Variants
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● Macular variant: tan-brown background with dark flat speckles in relatively even distribution resembling polka dots; associated with phacomatosis pigmentovascularis
● Papular variant: light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map; small dark macules may be present; associated with phacomatosis pigmentokeratotica or speckled lentiginous nevi syndrome (Dermatology 2006;212:53)
Case reports
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● With melanoma (Int J Dermatol 2006;45:1362)
Treatment and prognosis
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● Excision of speckles or entire lesion
Clinical images
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Various images
Hybrid nevus #1
Micro description
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● Macular variant - ‘jentigo' pattern (lentiginous pattern plus nests of melanocytes at dermal-epidermal junction) in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, but background pigmentation has microscopic features of lentigo
● Papular variant - dermal or compound melanocytic nevi
Micro images
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Nests of small and monomorphic melanocytes at the dermoepidermal junction and within the reticular dermis, with many melanocytes concentrated around blood vessels and adnexal structures
Videos
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Additional references
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● Cutis 2007;80:465, eMedicine
End of Skin-Melanocytic Tumors > Speckled lentiginous nevus
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