Home Chapter Home Jobs Conferences Fellowships Books
Skin-Melanocytic tumors
Nevus of Ota
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Revised: 16 February 2010, last major update November 2008
Copyright: (c) 2005-2009, PathologyOutlines.com, Inc.
Definition
=========================================================================
● First described by Ota in 1939 (Tokio Med J 1939;63:1243)
● Uncommon hamartoma in periorbital and temporal skin
Terminology
=========================================================================
● Also called oculodermal melanosis
Epidemiology
=========================================================================
● Usually Orientals, also Hispanics, blacks, Native Americans
● 60% have lesions at birth, 87% female, 60% have dermal and ocular involvement (Indian J Dermatol Venereol Leprol 2008;74:125)
Clinical
=========================================================================
● Tends to persist and extend locally, becoming increasingly prominent with age, puberty and postmenopausal state
● Associated with ipsilateral glaucoma, intracranial melanocytosis; rarely with cutaneous, ocular or intracranial melanoma (Cutis 2008;82:25), vascular nevus (J Am Acad Dermatol 2008;58:88)
Types
=========================================================================
●
Type IA: Mild orbital type: distribution over upper and lower eyelids,
periocular and temple region
● Type IB: Mild zygomatic type: pigmentation in infrapalpebral
fold, nasolabial fold and the zygomatic region
● Type IC: Mild forehead type: involvement of forehead alone
● Type ID: Involvement of ala nasi alone
● Type II: Moderate type: distribution over upper and lower
eyelids, periocular, zygomatic, cheek and temple regions
● Type III: Involves scalp, forehead, eyebrow and nose
● Type IV: Bilateral
Reference: Tanino, Jpn J Dermatol 1939;46:435
● Hori’s nevus: acquired bilateral nevus of Ota-like macules (J Am Acad Dermatol 1984;10:961, Dermatol Online J 2005;11(4):1); usually Chinese women with family history, become more confluent and gray over time (Br J Dermatol 2006;154:50)
● Sun’s nevus: acquired unilateral nevus of Ota
Case reports
=========================================================================
● With iris melanoma (Surv Ophthalmol 2008;53:411)
● 47 year old light-skinned non-Asian woman (Dermatol Online J 2007;13(3):19)
● Bilateral with oral mucosa involvement (Indian J Dermatol Venereol Leprol 2002;68:104)
● Acquired Ito's nevus in Caucasian elderly woman (J Cutan Pathol 2007;34:640)
● Acquired bilateral nevus (Dermatol Online J 2005;11(4):1)
Treatment and prognosis
=========================================================================
● Cosmetic coverup products
● Multiple sessions of laser photothermolysis to avoid darkening and extension, beginning early after diagnosis (Dermatol Surg 2007;33:455)
● Combined skin abrasion and carbon dioxide snow method (Plast Reconstr Surg 1996;97:544); cryosurgery and microsurgery not recommended due to scarring; chemical bleaching not recommended due to depigmentation
Clinical description
=========================================================================
● Macule with irregular blue-gray pigmentation in distribution of 1st and 2nd division of trigeminal nerve
Clinical images
=========================================================================
Flat blue-gray pigmentation Acquired dark brown spots below eyes
with an irregular border
on the skin of lateral ocular areas
Bilateral acquired nevus of Ota like macules Episcleral involvement
Micro description
=========================================================================
● Deeply pigmented dendritic melanocytes and melanophages dissecting bundles of dermal collagen in reticular dermis
Micro images
=========================================================================
Bipolar dendritic melanocytes in papillary and reticular dermis are arranged as single units between collagen bundles, also numerous pigment-laden macrophages
Contributed by Dr. Asmaa Gaber:
Other images: wavy dendritic cells with evenly dispersed melanin granules are distributed in the superficial reticular dermis
Additional references
=========================================================================
End of Skin-Melanocytic Tumors > Nevus of Ota
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by Copyright, (c) 2001-2009, PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions.