Skin - Nonmelanocytic tumors
Adnexal tumors - sebaceous glands
Sebaceous carcinoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 13 October 2016, last major update June 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Sebaceous carcinoma [title] skin

Cite this page: Sebaceous carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skintumornonmelanocyticsebaceouscarcinoma.html. Accessed August 16th, 2017.
Definition / general
  • Rare
  • Periocular vs. extraocular types
  • Tumors of eyelids, caruncles and orbit are more aggressive than extraocular tumors
  • May follow radiation therapy
  • Also associated with Muir-Torre syndrome (multiple cutaneous tumors with sebaceous and hair follicle differentiation and multiple internal malignancies; tumors have cystic growth pattern, Histopathology 2010;56:133)
Prognostic factors
  • Poor prognostic factors: necrosis
Case reports
Clinical images

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Presenting as BCC

On the superior right eyelid

Microscopic (histologic) description
  • Sebaceous differentiation, but also marked atypia, mitotic figures, invasion
Microscopic (histologic) images

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Images courtesy of Mark R. Wick, M.D.:

Grade 1

Grade 2

Grade 3

In situ, pilar unit

Squamoid variant

BerEP4+



Pagetoid

Neuroendocrine-like

CK7+

EMA+



Adipophilin+





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Full-thickness wedge resection

Scattered pleomorphic cells

Involving the lower eyelid

Positive stains
Negative stains
Differential diagnosis