Skin - Nonmelanocytic tumors
Other tumors of skin
Granular cell tumor

Author: Christopher Hale, M.D. (see Authors page)

Revised: 4 October 2016, last major update September 2012

Copyright: (c) 2001-2016, PathologyOutlines.com, Inc.

PubMed search: cutaneous granular cell [title] tumor

Cite this page: Granular cell tumor. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skintumornonmelanocyticgct.html. Accessed June 27th, 2017.
Definition / general
  • Also known as Abrikossoff's tumor
  • 2 / 3 of cases: are oral, occur in people of African descent, occur in women
  • Skin is most common extraoral site
  • 1 - 3% of soft tissue cases are malignant (Am J Surg Pathol 1998;22:779)
Case reports
Gross description
  • Nodule or plaque; rarely ulcerates
Gross images
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Arising on toe

Microscopic (histologic) description
  • Infiltrative tumor composed of large polyhedral cells with abundant granular cytoplasm and small, central nuclei
  • Often pseudoepitheliomatous hyperplasia, lysosomal inclusions (pustulo-ovoid bodies of Milian) usually present (J Cutan Pathol 2007;34:405)
Microscopic (histologic) images
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H&E

Positive stains
Negative stains
Differential diagnosis