Skin - Nonmelanocytic tumors
Adnexal tumors - hair follicles
Folliculofibroma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 6 October 2016, last major update June 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Hamartoma of hair follicle

Cite this page: Folliculofibroma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skintumornonmelanocyticfolliculofibroma.html. Accessed December 16th, 2017.
Definition / general
  • Considered a hamartoma of hair follicle

Birt-Hogg-Dubé syndrome
  • Folliculofibroma associated with Birt-Hogg-Dubé (BHD) syndrome
  • Autosomal dominant, multiple folliculomas on head and neck, acrocordons and trichodiscomas; also renal cell carcinoma [various types], renal oncocytoma and oncocytic hybrid tumors, lung cysts and spontaneous pneumothorax)
  • Human gene at 17p11.2 encodes folliculin, normally expressed in skin and adnexae (Mod Pathol 2004;17:998)
  • Frameshift mutations occur in BHD causing premature protein termination
Case reports
Clinical images

Images hosted on other servers:

Various images

Gross description
  • Multiple skin-colored papules
Microscopic (histologic) description
  • Thin epidermal strands originating from a central hair follicle with prominent connective tissue
Microscopic (histologic) images

Images hosted on other servers:

Various images

Differential diagnosis