Skin Nonmelanocytic tumors
Other tumors of skin
Collagenous fibroma

Author: Hillary Elwood, M.D. (see Authors page)

Revised: 26 April 2017, last major update April 2017

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Collagenous fibroma
Cite this page: Collagenous fibroma. website. Accessed June 23rd, 2017.
Definition / general
  • Also called desmoplastic fibroblastoma
  • Benign soft tissue tumor that usually occurs in the subcutis or skeletal muscle, rarely dermal involvement
  • Typically arises in 5th or 6th decade of life, slowly growing mass, 4 cm or less in size
  • Arise more commonly in men
  • Most common location is upper extremity
Case reports
Microscopic (histologic) description
  • Well circumscribed hypocellular lesion
  • Bland stellate and spindled fibroblasts with prominent collagenous to myxoid matrix
  • No necrosis and minimal or absent mitoses
  • Can have scattered blood vessels, sometimes with perivascular hyalinization
Microscopic (histologic) images

Images hosted on Pathout server:
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Contributed by Hillary Elwood, M.D.

Differential diagnosis
  • Neurofibroma: S100+; neural cells in myxoid stroma
  • Fibromatosis: much more cellular, often fascicular growth pattern
  • Elastofibroma: typically on shoulder, has prominent wavy elastic fibers