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Skin-melanocytic tumor
Melanoma
Invasive - general

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 29 May 2013, last major update May 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Epidemiology
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Populations at higher risk:
Sites
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Clinical warning signs
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Clinical features
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Physiology
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Regression
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Metastases
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Survival
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Poor prognostic factors
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Possible poor prognostic factors:
Case reports
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Diagnosis and Treatment
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Clinical images
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Scaly erythematous crusty pigmentation and thickened
plaques on the nipple, spreading to surrounding areola
Dermoscopy
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Micro description
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4 major subtypes: (described separately)
Regressed melanoma:
Other microscopic features
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Micro images
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Primary melanoma and epidermotropic metastases
Thin and thick melanoma
Vascular invasion
Ulceration
Satellite metastasis
Tumor infiltrating lymphocytes
Confocal microscopy versus H&E
Nipple melanoma, nodular type
HMB45+
PMEL17

Punch biopsy - depth of invasion was incorrect since it was measured along hair follicle that was not initially evident:
No hair follicle seen
Hair follicle seen on recut
Excision

Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain:
Pagetoid extension
Follicular growth
Cytology description
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Positive stains
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Distinguish melanocytes from non-melanocytes, but not malignant cells from benign cells: Electron microscopy description
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Molecular description
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Differential diagnosis
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Helpful features of melanoma that differentiate from benign lesions (from Rosai):
End of Skin-melanocytic tumor > Melanoma > Invasive - general


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