Skin-melanocytic tumor
Nevi
Compound nevus

Author: Christopher Hale, M.D. (see Authors page)

Revised: 1 February 2017, last major update March 2013

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: compound nevus
Cite this page: Compound nevus. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skintumormelanocyticcompoundnevus.html. Accessed November 19th, 2017.
Definition / general
  • Features of both junctional and intradermal nevi (i.e. epidermal and dermal components)
Terminology
  • Compound = junctional AND intradermal components
  • Do not confuse with combined nevus
Epidemiology
Clinical features
  • Elevated or dome shaped
  • Less pigmented than junctional nevi
  • Only rarely undergoes malignant transformation
  • Nevogenesis may be due to ultraviolet light (Am J Dermatopathol 2005;27:456)
Clinical images

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Eccentric hyperpigmented nevus suspicious for melanoma

Case reports
Microscopic (histologic) description
  • Features of both junctional and intradermal nevi (i.e. epidermal and dermal components)
  • Junctional component is similar to junctional nevus, with nests regularly distributed at bases of rete ridges, occasional lentiginous pattern, no pagetoid spread, no atypia, symmetry diminishes with patient age
  • Dermal component consists of nests (may be very large) or linear pattern of melanocytes, cells are small with scant cytoplasm and regular nuclei and mature with depth by becoming more slender / spindled with less pigment
  • Dermal melanocytes or nests are separated by collagenous stroma
  • Often clusters of chronic inflammatory cells at base of nevus
  • Mucin in < 1% (Am J Dermatopathol 2008;30:236)
  • May have occasional mitoses (Am J Dermatopathol 2013;35:30)
Microscopic (histologic) images

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With features of milk line nevus

Videos

Compound nevus with halo reaction
Differential diagnosis
  • Other melanocytic proliferations