Skin - Melanocytic tumor
Other pigmented lesions and disorders of pigmentation
Atypical melanocytic hyperplasia

Author: Christopher Hale, M.D. (see Authors page)

Revised: 24 February 2017, last major update March 2013

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PubMed Search: atypical melanocytic hyperplasia

Cite this page: Atypical melanocytic hyperplasia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skintumormelanocyticatypicalmelanocytichyperplasia.html. Accessed July 26th, 2017.
Definition / general
Terminology
  • Also called atypical melanocytic proliferation or benign atypical junctional melanocytic hyperplasia
Case reports
Microscopic (histologic) description
  • Atypical single unit melanocytes limited to epidermis, often seen at periphery of classic melanoma
  • In contrast to melanoma in situ, exhibits only focal confluence at dermoepidermal junction, has limited pagetoid spread and involves only upper hair follicle
  • Factors favoring atypical melanocytic hyperplasia over melanoma in situ (Mod Pathol 2000;13:857):
    • No lateral spread
    • No upward extension into epidermis
    • No finely granular, "smoky" melanin
    • No marked cytologic atypia
    • No mitotic figures
    • No host inflammatory fibrotic response
Microscopic (histologic) images

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Benign atypical junctional melanocytic hyperplasia

Differential diagnosis