Skin - Melanocytic tumor
Other pigmented lesions and disorders of pigmentation
Paraganglioma-like dermal melanocytic tumor

Author: Christopher Hale, M.D. (see Authors page)

Revised: 22 February 2017, last major update April 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Paraganglioma-like dermal melanocytic tumor

Cite this page: Paraganglioma-like dermal melanocytic tumor. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skintumormelanocyticPDMT.html. Accessed July 26th, 2017.
Definition / general
Epidemiology
  • Very rare; 8 of 30,000 consultation cases in one series
  • 75% females, mean age 35 years (range 18 - 53 years)
Clinical features
  • Dermal nodule, mean 1 cm
Case reports
Microscopic (histologic) description
  • Nested growth pattern similar to paraganglioma, composed of clear to amphophilic oval cells separated by delicate fibrous strands
  • No / mild nuclear atypia
  • 1 - 4 MF / 10 HPF
  • No melanin
  • Normal epidermis, no junctional activity
Microscopic (histologic) images

Images hosted on other servers:

Well demarcated nodule in dermis with normal epidermis

Tumor restricted to deep dermis

S100+

Various images

Neoplasm composed of organoid and nested groups of large epithelioid cells,
separated by delicate fibrous strands and prominent blood vessels; epithelioid
cells have somewhat clear cytoplasm, large nuclei with prominent red nucleoli

Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis