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Skin-Melanocytic tumors
Other melanocytic lesions - General
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Revised: 26 October 2009, last major update November 2008
Copyright: (c) 2005-2009, PathologyOutlines.com, Inc.
Patterns of benign behavior
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● Lentiginous hyperplasia (single cell melanocytic growth along dermoepidermal junction)
● Nested proliferation
● Pagetoid proliferation (discohesive single cell growth throughout entire epidermis-seen in Spitz nevi and acral nevi, as well as melanoma)
● Melanocyte nuclei are smaller than that of adjacent keratinocytes
Other benign features
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● Symmetric pattern of growth and involution, lateral dimension of dermal component is equal to that of original epidermal component
Maturation
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● Deeper portion of lesion has smaller cells with less pigment, less atypia
● Deep cells grow in smaller sized nests or single cells
● May resemble neural tissue
Case reports
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● Lentiginous hyperplasia associated with hamartoma (Am J Dermatopathol 2008;30:488) or dermatofibroma (J Dermatol 1996;23:840)
End of Skin-Melanocytic Tumors > Other melanocytic lesions - General
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