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Skin-Melanocytic tumors
Atypical melanocytic hyperplasia
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Revised: 26 October 2009, last major update November 2008
Copyright: (c) 2005-2009, PathologyOutlines.com, Inc.
Definition
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● Controversial topic
● Atypical hyperplasia (“atypical melanosis”) may occur on foot (Arch Dermatol 1994;130:1042, J Dermatol 2007;34:56) or on sun-damaged skin
Case reports
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● Associated with esophageal squamous cell carcinoma in situ (Virchows Arch 2000;437:203)
Micro description
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● Atypical single unit melanocytes limited to epidermis, often seen at periphery of classic melanoma
● As opposed to melanoma in situ, exhibit only focal confluence at the dermoepidermal junction, limited pagetoid spread and involvement of only the upper part of the hair follicles
Micro images
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Benign atypical junctional melanocytic hyperplasia
Differential Diagnoses
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● Melanoma in situ (Am J Dermatopathol 1996;18:560)
End of Skin-Melanocytic Tumors > Atypical melanocytic hyperplasia
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