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Skin-Melanocytic Tumors
Deep penetrating nevus
Last major update: November 2008 - next update November 2009
Revised: 28 June 2009
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Nevus whose dermal component extends into reticular dermis or subcutis
Clinical
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● First reported in 1989 (AJSP 1989;13:39)
● Uncommon lesion
● Usually face, neck, shoulder, less than 1 cm
● May be confused diagnostically with melanoma (J Plast Reconstr Aesthet Surg 2007;60:1252)
Case reports
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● Skin of cheek (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:e49)
● Linear arrangement of multiple deep penetrating nevi (Arch Dermatol 2003;139:1608)
Treatment and prognosis
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● Simple excision; only rarely recurs (Histopathology 2003;43:529)
Clinical images
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Linear distribution of nevi behind ear
Micro description
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● Nevus whose dermal component extends into reticular dermis or subcutis
● Cellular, nested or fascicular, with abundant pigment and mild atypia
● Usually inconspicuous junctional component
● No/rare mitotic figures, no/rare inflammation
● May be combined with other nevi
Micro images
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Various images
Various images
Differential Diagnoses
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● Melanoma - vertical growth phase - mitotic figures and marked atypia, ATM immunostaining may differentiate (Cancer Epidemiol Biomarkers Prev 2007;16:2486)
Additional references
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End of Skin-Melanocytic Tumors > Deep penetrating nevus
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