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Skin-Melanocytic Tumors
Compound nevus
Last major update: November 2008 - next update November 2009
Revised: 18 September 2009
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Features of both junctional and intradermal nevi (i.e. epidermal and dermal components)
Case reports
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● 17 year old woman with pigmented lesion on mons pubis (Archives 2003;127:e391)
● Compound nevus combined with Spitz nevus (J Dermatol 2000;27:233)
Clinical description
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●
Elevated or dome shaped
● Less pigmented than junctional nevi
● Only rarely undergoes malignant transformation
Dermoscopy images
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Cobblestone pattern with Peripheral regular pigmented Eccentric hyperpigmented nevus
“fitted” appearance of network, central homogeneous suspicious for melanoma
globules area and central black dots
Micro description
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● Features of both junctional and intradermal nevi (i.e. epidermal and dermal components)
● Junctional component is similar to junctional nevus, with nests regularly distributed at bases of rete ridges, occasional lentiginous pattern, no pagetoid spread, no atypia, symmetry, and tendency to diminish with patient age
● Dermal component consists of nests (may be very large) or linear pattern of melanocytes, cells are small with scant cytoplasm and regular nuclei, cells mature with depth by becoming more slender / spindled with less pigment
● Dermal melanocytes or nests are separated by collagenous stroma
● Often clusters of chronic inflammatory cells at base of nevus
● Mucin in < 1% (Am J Dermatopathol 2008;30:236)
● Dermal component does not stain with HBM45, has no mitoses, low labeling with Ki-67
Micro images
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Compound nevus with features of milk line nevus H&E and confocal scanning laser
microscopy
Confocal microscopy With underlying dermatofibroma Now Ki-67 compared to
melanoma
Video
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● Compound nevus with halo reaction, DermLectures.com
End of Skin-Melanocytic Tumors > Compound nevus
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