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Skin-nontumor / Clinical Dermatology

Other dermatoses

Weber-Christian disease

Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 1 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Also called relapsing febrile nodular panniculitis
● Recurring tender erythematous subcutaneous nodules of legs and trunk, usually in women, with malaise and fever
● Some cases are associated with other disorders
● No known risk factors


● Females 30-60 years of age, although can occur in both sexes, in all ages, and rarely in infants

Micro description

● Lobular acute and subacute inflammation of subcutis with fat cell necrosis; later fibrosis and macrophages

Differential diagnosis

Lipogranulomatosis subcutanea: no systemic symptoms, single lesions
Alpha-1-antitrypsin deficiency:
Chronic pancreatitis: associated with large areas of fat necrosis
Pancreatic endocrine tumors:

Additional references

eMedicine; J Postgrad Med 1984;30:49

End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Weber-Christian disease

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