Skin-nontumor / Clinical dermatology
Infectious disorders
Syphilis

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 1 June 2016, last major update March 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Syphilis [title] skin

Cite this page: Syphilis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumorsyphilis.html. Accessed December 7th, 2016.
Clinical Features
  • Secondary lesions occur on face and trunk; are maculopapular and resemble drug eruption, lichen planus and psoriasis
  • May present as moth-eaten alopecia on scalp, mucous patches on tongue
  • Diagnose by serology
  • Scaly, flesh-colored to erythematous papules or annular plaques
  • Copper macules on palms and soles
Clinical Images

Images hosted on PathOut servers:

Secondary, courtesy of Dr. Mark R. Wick

Gumma, courtesy of Dr. Mark R. Wick

Micro Description
  • Dense perivascular or diffuse plasma cell infiltrate with marked endothelial swelling and proliferation in blood vessels
  • May have noncaseating granulomas, vacuolar interface change, acanthosis, spongiosis or lymphocyte exocytosis
Micro Images

Images hosted on PathOut servers:

Secondary, breast skin, courtesy of Dr. Mark R. Wick

Steiner stain, secondary, courtesy of Dr. Mark R. Wick

Gumma, breast, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Primary syphilis

Positive Stains
  • Steiner stain (71% sensitive)