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Skin-nontumor / Clinical Dermatology

Other dermatoses

Synovial metaplasia

Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 2 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Metaplastic changes resembling synovium in non-joint spaces, usually in patients with prior surgery or traumatic injuries
● Synovial-type membranes may form against surface of suture material, tissue expanders or implants
● Associated with movement, loose areolar tissue that would develop spaces secondary to movement, and relatively smooth gliding surfaces that can resist penetration by fibroblasts (Arch Pathol Lab Med 2002;126:727)
● Membranes resemble joint (“true”) synovial membranes
● May be associated with cyst formation and transepidermal fistulae (Am J Surg Pathol 1987;11:343)

Clinical description

● Resemble suture granulomas

Micro description

● Resembles hyperplastic synovium

Micro images

Various images

Positive stains

● Vimentin (strong); scattered positivity with alpha-1-antichymotrypsin (alpha-1ACT) and lysozyme

Negative stains

● No basement membrane antigens or elastic fibers

End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Synovial metaplasia

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