Skin-nontumor / Clinical dermatology
Infectious disorders
Smallpox vaccination

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 1 June 2016, last major update September 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Smallpox vaccination [title]

Cite this page: Smallpox vaccination. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumorsmallpoxvaccination.html. Accessed December 7th, 2016.
Definition / General
  • Diffuse, pruritic, erythematous macules and papules that usually occur 7 - 11 days (range, 2 days to 7 weeks) after routine smallpox vaccination
Clinical Features
  • Serious but uncommon complications of smallpox vaccination include eczema vaccinatum, vaccinia necrosum, generalized vaccinia and encephalitis (Centers for Disease Control)
  • Less serious but more common complications include keloid, contact dermatitis, erythema multiforme, pityriasis rosea, granuloma annulare and vesicular spongiotic dermatitis with eosinophils (Arch Dermatol 2010;146:656)
Treatment
  • Symptomatic
Clinical Images

Images hosted on other servers:

Normal "robust" reaction



Hyperemic and indurated band extending from vaccination site



Vaccinia necrosum

Micro Description
  • Smallpox vaccination: possible features include eczema vaccinatum, vaccinia necrosum, generalized vaccinia, keloid, contact dermatitis, erythema multiforme, pityriasis rosea, granuloma annulare and vesicular spongiotic dermatitis with eosinophils
  • Smallpox infection (historical features-smallpox has now been eradicated): variable degree of hyperkeratosis and acanthosis, ballooning degeneration of keratinocytes, cytoplasmic eosinophilic inclusion bodies and dermal chronic inflammatory cell infiltrate
Micro Images

Images hosted on other servers:

Various images