Skin-nontumor / Clinical dermatology
Other dermatoses
Scleredema of Buschke

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 21 July 2016, last major update August 2011

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PubMed Search: Scleredema of Buschke

Cite this page: Scleredema of Buschke. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumorscleredema.html. Accessed December 9th, 2016.
Definition / General
  • Nonpitting, woody induration of upper back skin; associated with diabetes
  • Rare primary mucinosis that presents with non pitting indurated edema and associated dermal hardening in the absence of any clinical abnormality
  • After viral infection, especially UTI or insidious onset with no prior acute illness
  • Occasionally associated with paraproteinemia, secondary hyperparathyroidism, rheumatoid arthritis, Sjogren’s syndrome, HIV infection and nuchal fibroma
Clinical Features
  • Symmetrical non pitting edema and dermal hardening, which affects the posterior and lateral aspect of the neck, face, upper trunk and upper limbs
  • Rarely affects lower abdomen and legs
Case Reports
Micro Description
  • Epidermis appear slightly thinned or normal
  • Thickened reticular dermis, often at expense of subcutaneous fat; eccrine glands in upper third of mid dermis
  • Collagen fibers are broadened, abnormally separated by clear spaces, which may contain mucin
  • May be mild chronic inflammatory cell infiltrate in superficial dermis, increased mast cells, but normal amount of fibroblasts
Negative Stains
  • Negative direct immunofluorescence
Differential Diagnosis
  • Scleroderma: appendages are atrophic or absent; diffuse dermal sclerosis, not the fenestrated appearance of scleredema
Additional References