Skin-nontumor
Other dermatoses
Nephrogenic systemic fibrosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 November 2016, last major update March 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Nephrogenic systemic fibrosis

Cite this page: Nephrogenic systemic fibrosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumornephrosystfibrosis.html. Accessed October 18th, 2017.
Definition / general
Clinical images

Images hosted on PathOut servers:

Courtesy of Joel Pinczewski, M.D., Ph.D.
The 53 year old woman in this photograph had end-stage renal failure
and underwent a gadolinium-enhanced MRI; several years later she developed
indurated and hyperpigmented skin lesions on her lower legs.

Microscopic (histologic) description
  • Elastic fibers:
    • Known as sclerotic bodies or “elastocollagenous balls”
    • Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images

Images hosted on PathOut servers:

Courtesy of Joel Pinczewski, M.D., Ph.D.
The H&E stained section reveals increased dermal mucin,
spindled fibroblasts and nodules of collagen containing entrapped elastic fibers