Skin-nontumor / Clinical dermatology
Other dermatoses
Massive localized lymphedema in morbidly obese patients

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 15 July 2016, last major update August 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Massive localized lymphedema [title]

Cite this page: Massive localized lymphedema in morbidly obese patients. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumormassivelocalizedlymphedema.html. Accessed December 7th, 2016.
Definition / General
  • Huge masses in thigh, popliteal fossa, scrotum, suprapubic region, inguinal region and abdomen of morbidly obese patients, lasting 1 - 8 years
  • Clinically resembles lipoma or recurrent cellulitis, but also suspicious for malignancy
  • May be due to obstruction of efferent lymphatics by prior surgery, massive abdominal pannus or hypothyroidism
Clinical Features
  • Nonencapsulated, poorly defined, mean 51 cm (range 38 - 75 cm), mean weight 6.8 kg (range 2 - 12 kg)
  • Overlying skin has marbled appearance resembling chronic lymphedema with induration and peau díorange
Micro Description
  • Fibrous bands intersect lobules of adipose tissue
  • Lymphatic vascular ectasia, chronic inflammatory infiltrate, edema between collagen fibers, infarction and fat necrosis
  • No atypia
Micro Images

Images hosted on PathOut servers:

Courtesy of Mark R. Wick, M.D.

Differential Diagnosis