Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Skin-nontumor / Clinical Dermatology

Other dermatoses

Malignant atrophic papulosis

Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 1 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Intimal proliferation of deep-seated arterioles which causes infarcts
● Dego's disease: variant causing a lethal syndrome, involving small bowel, heart, lungs, kidney, bladder and liver
● Also benign and familiar variants

Clinical description

● Discrete small patches composed of a central zone with a depressed white, porcelain like appearance and a fine scale surrounded by a narrow red or violaceous rim associated with a fine telangiectasia
● Skin lesions affect the trunk and proximal extremity

Clinical images

Various images

Micro description

● Epidermis is hyperkeratotic and atrophic
● Wedge shaped dermal infarct with the base parallel to the surface epithelium
● Pale in color, relatively acellular
● Mucin deposition common
● Older lesions are frequently ulcerated
● Vessels adjacent to and deep to the infarct show a perivascular lymphocytic infiltrate
● Endovasculitis in dermal vessels with endothelial cell hyperplasia and complicated by thrombosis
● Panniculitis mimicking lupus erythematosus profundus has been described
● Microscopic examination of bowel reveals transmural intestinal inflammation with ulceration and hemorrhage

Differential diagnosis

● SLE, systemic sclerosis, rheumatoid arthritis, dermatomyositis, Crohn’s disease

Additional references


End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Malignant atrophic papulosis

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).