Skin-nontumor / Clinical dermatology
Other dermatoses
Malignant atrophic papulosis

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 15 July 2016, last major update August 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Malignant atrophic papulosis

Cite this page: Malignant atrophic papulosis. website. Accessed October 26th, 2016.
Definition / General
  • Intimal proliferation of deep-seated arterioles which causes infarcts
  • Dego's disease: variant causing a lethal syndrome, involving small bowel, heart, lungs, kidney, bladder and liver
  • Also benign and familiar variants
Clinical Features
  • Discrete small patches composed of a central zone with a depressed white, porcelain like appearance and a fine scale surrounded by a narrow red or violaceous rim associated with a fine telangiectasia
  • Skin lesions affect the trunk and proximal extremity
Micro Description
  • Epidermis is hyperkeratotic and atrophic
  • Wedge shaped dermal infarct with the base parallel to the surface epithelium
  • Pale in color, relatively acellular
  • Mucin deposition common
  • Older lesions are frequently ulcerated
  • Vessels adjacent to and deep to the infarct show a perivascular lymphocytic infiltrate
  • Endovasculitis in dermal vessels with endothelial cell hyperplasia and complicated by thrombosis
  • Panniculitis mimicking lupus erythematosus profundus has been described
  • Microscopic examination of bowel reveals transmural intestinal inflammation with ulceration and hemorrhage
Differential Diagnosis
Additional References