Skin-nontumor / Clinical Dermatology - Lichen simplex chronicus

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Skin-nontumor / Clinical Dermatology

Other dermatoses

Lichen simplex chronicus

Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC (see Reviewers page)
Revised: 26 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Plaque like condition due to chronic rubbing and scratching

Terminology
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● Also called neurodermatitis

Clinical description
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● Thick, scaly plaques with erythema, well demarcated from surrounding skin
● Associated with excoriation, lichenification, crusting
● Raised nodules are called prurigo nodularis

Micro description
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● Marked hyperkeratosis associated with foci of parakeratosis
● Prominent granular cell layer
● The epidermal rete are elongated and irregularly thickened
● Mild spongiosis
● Perivascular and interstitial inflammation with histiocytes, lymphocytes and occasional eosinophils in superficial dermis
● Occasionally enlarged elongated myofibroblasts, papillary dermal fibrosis, nerve hyperplasia

Additional references
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● eMedicine

End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Lichen simplex chronicus

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