Skin-nontumor / Clinical Dermatology
Reviewer: Mowafak Hamodat, MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns, Canada (see Reviewers page)
Revised: 31 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Disorder of epidermal maturation in which skin resembles fish scales
● Associated with excessive keratin buildup due to a desquamation defect, leading to retention of abnormally formed scale
● Usually apparent at birth
● In adults, is associated with malignancies (lymphoma, carcinoma of bronchus, breast and cervix), sarcoidosis, lupus and drugs
● Ichthyosis vulgaris: common type
● Lamellar ichthyosis: rare inherited skin condition of newborn with shedding of plate-like layers of skin
● X linked variant: deficiency in steroid sulfatase, which removes proadhesive cholesterol sulfate from intracellular spaces
● Skin resembles fish scales; rough scaly patches and plaques
● Increased stratum corneum with loss of normal basket weave pattern, minimal inflammation
● Loss of granular layer in ichthyosis vulgaris
● X-linked variant
● Lamellar ichthyosis
● Ichthyosis vulgaris
End of Skin-nontumor / Clinical Dermatology > Other dermatoses > Ichthyosis
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