Skin-nontumor / Clinical dermatology
Infectious disorders
Fungi - Zygomycosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 May 2016, last major update July 2011

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PubMed Search: Fungi - Zygomycosis [title]

Cite this page: Fungi - Zygomycosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumorfungizygomycosis.html. Accessed December 4th, 2016.
Clinical Features
  • Infections caused by fungi in class Zygomycetes, including Absidia, Mucor, Rhizomucor, Rhizopus, Apophysomyces elegans (rare human pathogen)
  • Most zygomycosis occur in immunocompromised patients (due to leukemia, lymphoma, diabetes, transplantation), with rhinocerebral or pulmonary infection, then dissemination
  • Other causes include iron overload, major trauma, chronic corticosteroids, intravenous drug use / injection abscess (Indian J Med Res 2010;131:765), neonatal prematurity, malnourishment
  • A. elegans causes progressive necrosis of wound in previously healthy patients after trauma or invasive procedures (Arch Pathol Lab Med 1999;123:386)
Diagnosis
  • PCR or culture
  • A. elegans - grows as a rapidly growing mold with sporangiophores having dark brown, funnel shaped apophyses and pyriform sporangia
Treatment
Clinical Images

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Rhizomucor culture has "cotton candy" like texture, grows rapidly, maturation within 4 days



Rhizomucor culture demonstrates sparsely septate broad hyphae, irregularly branched sporangiophores, brown round sporangia, rhizoids located on stolons between sporangiophores

Micro Description
  • Extensive coagulative necrosis due to fungi with broad, sparsely septate, thin-walled hyphae
  • Angioinvasion with thrombosis
Micro Images

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Aseptate hyphae

Additional References