Skin-nontumor / Clinical Dermatology
Erythema toxicum neonatorum
Reviewer: Mowafak Hamodat MB.CH.B, MSc., FRCPC, Eastern Health, St. Johns (Canada) (see Reviewers page)
Revised: 8 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Skin condition in 50% of newborns, with red patches on forehead, face, chest, trunk and extremities that have raised clear bumps in the center; usually resolves within a few days without treatment
● Pathogenesis unknown; may be an acute graft versus host reaction, resulting from the transfer of maternal lymphocytes during delivery
● Erythematous pustular eruption
● Can be diagnosed clinically based on classic appearance (Am Fam Physician 2008;77:47)
Red patches with raised clear central bumps
● Intraepidermal pustule (subcorneal) filled with eosinophils and occasional neutrophils
● Early erythematous lesion shows perivascular inflammatory cell infiltrate with conspicuous eosinophils
● Incontinentia pigmenti: prominent eosinophilic spongiosis, not seen in erythema toxicum neonatorum
● Miliaria rubra (heat rash): vesicles are related to sweat ducts, not hair follicles, and typically contain mononuclear cells, not eosinophils
End of Skin-nontumor / Clinical Dermatology > Blistering disorders > Erythema toxicum neonatorum
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