Skin-nontumor / Clinical dermatology
Other dermatoses
Erythema elevatum diutinum

Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 June 2016, last major update July 2011

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PubMed Search: Erythema elevatum diutinum

Definition / General
  • Bilaterally symmetric erythematous or violaceous plaques or nodules, often over outer surface of joints
  • Systemically ill patients or associated with HIV
  • May be related to granuloma faciale
  • May be an immune-complex vasculitis induced by chronic antigen exposure
Case Reports
Clinical Images

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Firm brown tumors on extensor surfaces of extremities

Gross Images

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Nodules removed from hand

Micro Description
  • Leukocytoclastic vasculitis, progressing to fibrosis and onion skinning around vessels
  • Extracellular lipid deposits may be present in late lesions; no / rare eosinophils
Micro Images

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Small vessel vasculitis

Whorled fibromatous pattern

Differential Diagnosis
  • Localized chronic fibrosing vasculitis: different clinical findings
Additional References