Skin-nontumor / Clinical dermatology
Other dermatoses
Cytophagic histiocytic panniculitis

Author: Mowafak Hamodat, M.D., MB.CH.B, MSc., FRCPC (see Authors page)

Revised: 24 June 2016, last major update July 2011

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PubMed Search: Cytophagic histiocytic panniculitis

Cite this page: Cytophagic histiocytic panniculitis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/skinnontumorcytophagichistiocyticpanniculitis.html. Accessed December 8th, 2016.
Definition / General
Terminology
  • Panniculitis associated with hemophagocytic syndrome
Etiology
  • Associated with CMV, EBV, HIV, bacteria, fungi and parasites
  • Occurs post-bone marrow transplant, with SLE, as adverse reaction to interferon–alpha therapy
  • Associated with T cell lymphoma
  • Presents with spiking fever, erythematous subcutaneous skin nodules, anemia, leukopenia
  • May be fatal with multisystemic involvement
Clinical Features
  • Erythematosus to violaceous or hemorrhagic nodules, often in lower limbs and trunk
  • Ulceration with localized or generalized edema
Clinical Images

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Cytophagic histiocytic panniculitis

Micro Description
  • Lobular or partially septal distribution of florid lobular panniculitis, with large histiocytes containing eosinophilic cytoplasm; also neutrophils and lymphocytes
  • Red cell extravasation typically present with frank hemorrhage
  • Erythrophagocytosis, phagocytosis of lymphocytes or nuclear debris
  • Enlarged histiocytes may be described as "bean bag cell"
  • Usually no giant cells / granulomas
Micro Images

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11 year old girl with perforin gene mutation

Differential Diagnosis
  • Angiocentric lymphoma
  • Cutaneous Rosai Dorfman disease
  • Subcutaneous T cell panniculitis lymphoma