Skin-nontumor- Annular elastolytic giant cell granuloma

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Other dermatoses

Annular elastolytic giant cell granuloma

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 18 July 2011, last major update July 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Erythematous or brown annular infiltrate in face, neck or dorsa of hands of elderly or heavily sun-exposed individuals
● May be a variant of granuloma annulare

Terminology
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● Also called O’Brien’s actinic granuloma or Miescher’s granuloma

Case reports
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● 45 year old woman with growing lesion in neck (Dermatol Online J 2011;17:7)

Clinical images
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Raised forehead lesion

Neck lesion

Micro description
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● Dermis in region of rim has histiocytes and foreign body giant cells engulfing elastotic fibers (elastoclasis)
● Also variable lymphocytes, plasma cells and eosinophils
● Usually no necrobiosis, no increased dermal mucin

Micro images
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Granulomatous infiltrate of multinucleated giant cells in upper reticular dermis

Elastophagocytosis and loss of elastic fibers in center of lesion (orcein staining)

Differential diagnosis
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● Granuloma annulare and necrobiosis lipoidica usually have necrobiosis, increased dermal mucin

End of Skin-nontumor > Other dermatoses > Annular elastolytic giant cell granuloma

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