Salivary glands
Inflammation
Kimura disease

Author: Sally Tanakchi, M.B.Ch.B. (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 29 October 2015, last major update October 2015

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Kimura disease [title] salivary
Cite this page: Kimura disease. PathologyOutlines.com website. http://pathologyoutlines.com/topic/salivaryglandskimura.html. Accessed November 18th, 2017.
Definition / general
  • Rare chronic inflammatory disorder involving deep subcutaneous tissue of head and neck, often with lymphadenopathy and salivary gland involvement
  • Renal involvement has also been reported
  • Usually Asian males with elevated serum IgE and eosinophilia
  • US study showed 85% males, mean 32 years old, range 8 - 64 years (Am J Surg Pathol 2004;28:505)
  • May clinically simulate a neoplasm
  • Chronic and indolent; rarely causes death
  • Unknown infectious agent is presumed to cause an immunologic response
Case reports
Treatment
  • Surgery; may recur
Microscopic (histologic) description
  • Follicular hyperplasia, eosinophilic infiltrates, post-capillary venule proliferation with variable degree of fibrosis
Microscopic (histologic) images
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Parotid gland

Differential diagnosis