Salivary glands
Epithelial / myoepithelial tumors
Dermal analogue tumor

Reviewer: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 7 January 2016, last major update September 2012

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PubMed Search: Dermal analogue tumor salivary

Related: Basal cell adenoma
Cite this page: Dermal analogue tumor. PathologyOutlines.com website. http://pathologyoutlines.com/topic/salivaryglandsdermalanaloguetumor.html. Accessed January 23rd, 2018.
Definition / general
  • Uncommon subtype of basal cell monomorphic adenoma with clinical and histological resemblance to dermal cylindroma
  • First described in 1974 by Drut and in 1977 by Headington and Reingold (Cancer 1977;39:2460, Cancer 1977;40:1702)
  • Also called membranous tumor
Clinical features
  • Usually in parotid gland or intranodal parotid gland, ectopic salivary gland in lymph nodes (periparotid, cervical, Cancer 1987;59:1165)
  • Sporadic or familial
  • Histogenesis: germinal epithelium of ectodermal origin
  • Usually men, mean age 60 years old
  • 25-38% have cutaneous tumors
  • Occasionally coexists with multiple dermal cylindromas (Brooke-Spiegler syndrome, autosomal dominant salivary gland-skin adnexal tumor syndrome, Head Neck 2010;32:684), Warthin tumor
  • Multicentricity and multiple recurrencies
  • Long period of follow-up required
  • Treat with resection, but 25-37% recur, 28% undergo malignant transformation to basaloid adenocarcinoma with destructive infiltrative growth beyond gland margins and perineurial or vascular invasion, but not necessarily pleomorphism, necrosis or mitotic activity
Gross description
  • Usually unencapsulated, 50% multifocal, up to 3.5 cm
Microscopic (histologic) images

Images hosted on other servers:

Various images

Jigsaw patterns of basaloid nests

Cytology description
Positive stains
  • PAS
Molecular / cytogenetics description
Differential diagnosis