Prostate
Microscopic mimics of prostatic carcinoma
Mesonephric remnants / hyperplasia

Author: Andres Matoso, M.D. (see Authors page)

Revised: 27 July 2016, last major update July 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Mesonephric remnants

Cite this page: Mesonephric remnants / hyperplasia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/prostatemesonephrichyper.html. Accessed August 21st, 2017.
Definition / general
  • Mesonephric remnants / hyperplasia is a proliferation of small glands that mimic prostatic carcinoma
  • This is more common in the female genital tract and can rarely be seen within the prostate
Essential features
  • Cluster of small acini with eosinophilic secretion, cells with bland nuclei and inconspicuous nucleoli usually in a lobular distribution
  • An infiltrating pattern can be seen occasionally, mimicking cancer
  • Papillary infolding or small ill formed glands may mimic high grade prostate cancer
  • No clinical significance
Epidemiology
  • Mean age 60 years (range, 40 to 80 years)
Sites
  • Prostate and periprostatic tissue
Pathophysiology
  • Believed to represent an embryologic remnant
Clinical features
  • Asymptomatic
Prognostic factors
  • Not associated with increased risk of cancer
Treatment
  • Not required
Microscopic (histologic) description
  • Cluster of small acini with eosinophilic secretion, with cells with bland nuclei and inconspicuous nucleoli usually in a lobular distribution
  • An infiltrating pattern can be seen occasionally, mimicking cancer
  • Papillary infolding or small ill-formed glands may mimic high grade prostate cancer
Microscopic (histologic) images

Images hosted on PathOut servers:

Courtesy of Andres Matoso, M.D.

Positive stains
  • High molecular weight cytokeratin and p63 are typically positive but can be negative
  • Racemase can be focally positive; when positive, along with negative p63 and high molecular weight cytokeratin, can erroneously lead to a diagnosis of adenocarcinoma of the prostate
  • PAX8 is positive
Negative stains
Differential diagnosis