Other carcinomas

Authors: Komal Arora, M.D. (see Authors page)

Revised: 15 August 2016, last major update March 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: prostatic carcinosarcoma
Cite this page: Carcinosarcoma. website. Accessed December 12th, 2017.
Definition / general
  • Also known as sarcomatoid carcinoma, metaplastic carcinoma, spindle-cell carcinoma, and malignant mixed mesodermal tumour
  • Rare (< 30 patients)
  • May represent sarcomatoid transformation of prior adenocarcinoma or be related to radiotherapy or hormonal therapy
  • Aggressive clinical course (Am J Surg Pathol 2006;30:1316)
Microscopic (histologic) description
  • Biphasic tumor with adenocarcinoma and recognizable sarcoma components (chondrosarcoma, rhabdomyosarcoma, angiosarcoma, osteosarcoma, leiomyosarcoma)
Positive stains
Negative stains
  • Sarcoma component negative for PSA, EMA, keratin
Differential diagnosis
  • Primary prostatic sarcoma, benign spindle cell proliferations such as inflammatory myofibroblastic tumor (pseudosarcomatous fibromyxoid tumor) and postoperative spindle cell nodule can be confused with the mesenchymal component of sarcomatoid carcinoma; note that in recurrent tumors, the mesenchymal component usually overgrows the epithelial component and so a pure sarcomatous pattern in the setting of pretreated adenocarcinoma should be assumed to represent sarcomatoid carcinoma
Additional references