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Infectious conditions

Villitis of unknown etiology (VUE)

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Chronic inflammatory cells within stroma of chorionic villi
● No causative organism
● Infiltrating cells have been shown to be maternal T cells, suggesting that this is an immune-mediated disease
● Associated with fetal growth restriction, premature delivery and stillbirth (more common with recurrent disease)
● Seen in 3-5% of placentas with greater incidence (25%) in small for gestational age newborns

Micro description

● Lymphocytes and macrophages within the villous stroma, sometimes with granulomas and giant cells
● May be accompanied by chronic deciduitis with plasma cells, chronic chorioamniotis, perivillous fibrin, avascular villi and rarely with chronic intervillositis


● Focal (low grade): small clusters of villi (<10) on a single slide
● Multi-focal (low grade): small clusters of involved villi (<10) on multiple slides
● Patchy (high grade): larger clusters of villi (>10) on multiple slides
● Diffuse (high grade): large clusters of villi (>10) on all slides

End of Placenta > Infectious conditions > Villitis of unknown etiology (VUE)

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