Placental findings in specific newborn/fetal or maternal conditions
Thrombosis of fetal arteries
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 17 November 2011, last major update November 2011
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● Thrombosis of fetal vessels results in fibrosis of downstream villi
● Thrombi may also embolize to fetal organs, resulting in perinatal asphyxia and an increased risk of neurologic injury
● More common in diabetic pregnancies, often associated with increased syncytial knots, fibrotic villi, Langhans cells and villous fibrinoid necrosis
● Triangular or hemispheric pale areas, seen better after formalin fixation or otherwise similar to remaining placenta
● Occlusive thrombi in large stem vessels accompanied by downstream changes, including loss of vascularity and fibrosis
Avascular villi (figure 1A)
● Placental infarction
● Villous edema
● Villous immaturity
End of Placenta > Placental findings in specific newborn/fetal or maternal conditions > Thrombosis of fetal arteries
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