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Specific Fetal and Maternal Conditions

Sickle Cell Disease

Reviewers: Mandolin Ziadie, M.D., (see Reviewers page)
Revised: 12 November 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Maternal disorder of hemoglobin synthesis associated with an increased risk of intrauterine fetal demise or growth restriction

Case report

● 28 year old woman with sickle cell trait (Arch Pathol Lab Med 2000;124:1565)

Micro description (Histopathology)

● Multiple findings include infarction, sickled red blood cells, intervillous hemorrhage, Tenney-Parker change, decidual vasculopathy, villous fibrosis

Micro images

Many of the maternal red blood cells in this placenta are sickle shaped

Electron microscopy description

● Umbilical vein shows smooth muscle proliferation, increase in basement membrane thickness, necrosis reduplication of inner elastic lamina (Hum Pathol 1999;30:13)

End of Placenta > Specific Fetal and Maternal Conditions > Sickle Cell Disease

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