Placenta
Gestational trophoblastic disease
Hydatidiform mole, general

Author: Sonali Lanjewar, M.D., MBBS (see Authors page)
Editor: Raavi Gupta, M.D.

Revised: 31 August 2017, last major update August 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Placenta hydatidiform mole[title]
Cite this page: Lanjewar, S. Hydatidiform mole, general. PathologyOutlines.com website. http://pathologyoutlines.com/topic/placentahydatgeneral.html. Accessed November 22nd, 2017.
Epidemiology
  • Risk factors: history of prior mole, primigravid state, southeast Asian / African / Latin American origin, extremes of reproductive age and Vitamin A precursor deficiency
Clinical features
  • Hydatidiform mole is an abnormal placenta characterized by enlarged, edematous and vesicular chorionic villi accompanied by villous trophoblastic hyperplasia
  • Frequency of hydatidiform moles is higher in Asia and Middle East (100 - 1000/100,000 pregnancies) compared to North America and Europe (100 per 100,000 pregnancies) (Lancet Oncol 2003;4:670)
  • Hydatidiform mole is subdivided into complete and partial hydatidiform mole based on morphologic, cytogenetic and clinicopathological features
  • All molar pregnancies have the potential for persistent GTD (Lancet Oncol 2003;4:670)
  • Complete moles outnumber partial moles in frequency (Am J Surg Pathol 2008;32:445, Am J Obstet Gynecol 2007;196:172.e1) and carry a higher risk of gestational trophoblastic disease
Treatment
  • Surgical curettage is the preferred mode of treatment