Placental gross/microscopic abnormalities, non-neoplastic
Increased perivillous fibrin
Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update October 2011
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● Small amounts of fibrin are commonly scattered throughout the normal placenta
● Diffusely increased amounts of perivillous fibrin involving stem and terminal villi and large enough to be grossly visible are a significant pathologic finding
● Increased fibrin may impair gas exchange and lead to growth restriction, oligohydramnious, premature birth (Arch Pathol Lab Med 1994;118:698), neurologic impairment or fetal death
● Strands of pale, firm parenchyma
● Abundant perivillous fibrin that obliterates the intervillous space with loss of the syncytiotrophoblast
● Requires at least one area of full-thickness involvement / entrapment of at least half of the villi on a single slide
End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Increased perivillous fibrin
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