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Infectious conditions

Chronic intervillositis (Massive chronic intervillositis)

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Diffuse histiocytic infiltrate in intervillous space
● Associated with perinatal mortality of 80%, making it an important (although uncommon) cause of recurrent spontaneous abortion (Arch Pathol Lab Med 1993;117:1032, Hum Pathol 2000;31:1389)
● Maternal risk factors: diabetes, hypertension, intravenous drug abuse, preeclampsia and systemic lupus erythematosus; may have immunologic origin (IgM and complement deposits are seen in vascular lesions)
● High recurrence rate (67%)
● Associated with recurrent abortion (Hum Pathol 1995;26:1245), growth restriction (Am J Surg Pathol 1998;22:1006, Hum Pathol 2001;32:1022) and fetal death

Gross description

● Small placenta

Micro description

● Diffuse infiltrate of histiocytes within intervillous space with villous fibrinoid deposits
● Other associated lesions may include atherosis, acute chorioamnionitis and rarely chronic villitis
● Malaria: associated with abundant fibrin, black pigment, occasional neutrophils and parasite-laden red blood cells

Positive stains

● CD68 (histiocytic marker)

Negative stains

● hCG (may be present in syncytiotrophoblasts, but marked reduction compared to usual)

End of Placenta > Infectious conditions > Chronic intervillositis (Massive chronic intervillositis)

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