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Placental gross/microscopic abnormalities, non-neoplastic

Amnion nodosum

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 10 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Small deposits on fetal surface


● Seen in placentas affected by oligohydramnios, which may be associated with fetal renal agenesis and pulmonary hypoplasia
● May be due to desquamated skin or membrane injury

Gross description

● Multiple yellow-tan superficial amniotic lesions, 0.2 to 0.4 cm and usually near insertion of umbilical cord

Micro description

● Nodules of protuberant eosinophilic fibrinous material with entrapped squamous cells
● Associated with stratified squamous metaplasia

Micro images

Image #1, #2

End of Placenta > Placental gross/microscopic abnormalities, non-neoplastic > Amnion nodosum

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