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Gestational trophoblastic disease - general

Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 7 December 2011, last major update December 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Tumors (hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor) and tumor-like lesions (exaggerated placental site, placental site nodule) that are related to trophoblastic proliferation
● Tumors are rare (1 / 1000 pregnancies)
● Women at the extremes of reproductive age are at greatest risk for complete hydatidiform mole
● Traditional anatomic staging is not a useful prognostic indicator
● Poor prognostic indicators include duration > 4 months, pretreatment hCG > 40,000, brain or liver metastases, gestational trophoblastic disease (GTD) after term gestation and failed therapy
● Recurrence / metastases is diagnosed with serum hCG

NIH Classification:
● Benign
● Malignant, non-metastatic
● Malignant, metastatic


● Methotrexate has cure rates near 100%, even in metastatic disease

End of Placenta > Gestational trophoblastic disease > General

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