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Exocrine tumors

Signet ring cell carcinoma

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 28 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Extremely rare, usually aggressive, poorly differentiated invasive adenocarcinoma with malignant glandular cells having nucleui pressed to one side by intracytoplasmic mucin (WHO)
● Must exclude breast or GI primary

Case reports

● 30 year old man (Ultrastruct Pathol 1998;22:147)

Micro description

● Poorly cohesive epithelial cells containing intracytoplasmic mucin that displaces nuclei towards periphery
● Infiltrates as single cells; variable extracellular mucin
● Resembles mammary lobular carcinoma and gastric carcinoma with targetoid pattern, signet ring cells, linear infiltration

Micro images

Strands of relatively small tumor cells with many signet-ring cells

Typical signet-ring cells

End of Pancreas > Exocrine tumors > Signet ring cell carcinoma

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