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Exocrine tumors

Tumors with rhabdoid features

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 30 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Case reports

● Non-specific feature of neuroendocrine tumors (Am J Surg Pathol 2003;27:642) and carcinomas, indicative of aggressive behavior
● Not a WHO diagnosis

Case reports

● 42 year old man with squamous cell carcinoma and osteoclast-like giant cells (J Clin Pathol 2006;59:1309)
● 52 year old woman with anaplastic carcinoma, apparently arising from mucinous cystadenocarcinoma (Arch Pathol Lab Med 1997;121:1104
● 59 year old man with anaplastic carcinoma (Med Mol Morphol 2007;40:168)
● 68 year old woman with anaplastic carcinoma (Pathol Int 2000;50:57)
● 75 year old man with adenosquamous carcinoma (JOP 2007;8:330)

Micro description

● Sheets of monotonous tumor cells with abundant densely eosinophilic cytoplasmic inclusions that displace the nuclei toward the periphery, uniform round nuclei, dispersed chromatin
● Rhabdoid elements merge with conventional areas
● Suggested that some cases be termed "with cytokeratin aggresomes" (J Clin Pathol 2004;57:1106)

Micro images

Adenosquamous carcinoma with rhabdoid features
Left-large cells with abundant eosinophilic cytoplasm with paranuclear aggregation of filaments, eccentric nuclei and prominent nucleoli
Right-cytokeratin stain highlights cytoplasmic aggregation of intermediate filaments

Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells

Authors described as "cytokeratin aggresomes", not rhabdoid

Positive stains

● Rhabdoid tumor cells: chromogranin, synaptophysin, cytokeratin

Electron microscopy description

● Cytoplasmic inclusions are composed of large whorls of intermediate filaments

End of Pancreas > Exocrine tumors > Tumors with rhabdoid features

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