Pancreas
Congenital anomalies
Heterotopic pancreas

Author: Deepali Jain, M.D. (see Authors page)

Revised: 7 December 2017, last major update August 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Heterotopic pancreas[TI] free full text[sb]

Cite this page: Jain, D. Heterotopic pancreas. PathologyOutlines.com website. http://pathologyoutlines.com/topic/pancreasheterotopic.html. Accessed December 13th, 2017.
Definition / general
Case reports
Gross description
  • 0.2 - 3 cm
  • Resembles normal pancreas with firm, yellow, well circumscribed, lobulated nodules
  • May have central umbilication due to a central duct if below a mucosa (can detect radiographically)
Microscopic (histologic) description
  • Usually in submucosa
  • Almost always acinar cells and ducts; islets present in 1/3
  • May be pyloric type mucous glands
  • 4 histologic types: total (all cell types), ducts only (canalicular), exocrine (acinar) only, islet cells only / endocrine (very rare, Arch Pathol Lab Med 2002;126:464)
  • May have convoluted branching pattern mimicking invasive carcinoma
  • Rarely retains mucus and resembles mucinous carcinoma (Am J Surg Pathol 1994;18:953)
Microscopic (histologic) images

Images hosted on PathOut server:

Stomach: purely endocrine

Stomach: heterotopic pancreas tissue in muscular layer contains ducts, acinar cells and a few islets



Images hosted on other servers:

Gastroesophageal junction

Jejunum

Liver:
heterotopic
pancreas / ductal
adenocarcinoma

Meckel diverticulum in Crohn's patient - figure 3

Stomach: purely endocrine

Differential diagnosis