Pancreas
Pancreatitis
Eosinophilic pancreatitis

Author: Deepali Jain, M.D. (see Authors page)

Revised: 8 December 2017, last major update August 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Eosinophilic pancreatitis[TIAB]

Cite this page: Jain, D. Eosinophilic pancreatitis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/pancreaseosinophilic.html. Accessed December 13th, 2017.
Definition / general
  • Very rare (< 20 cases reported)
  • Usually peripheral eosinophilia and multiorgan involvement (Am J Surg Pathol 2003;27:334)
  • May have elevated serum IgE
  • May have hypereosinophilic syndrome: eosinophil count > 1500 cells/mm3 sustained over ≥ 6 months, history of allergic manifestations such as rhinitis and bronchial asthma, involvement of other organ systems such as skin, heart, GI tract, no other recognizable cause for eosinophilia, including parasitic infections and leukemia
  • May present as a pancreatic mass or common bile duct obstruction simulating malignancy
Case reports
Microscopic (histologic) description
  • Diffuse periductal, acinar and septal eosinophilic infiltrate affecting arteries and veins or clusters of eosinophils associated with pseudocysts
  • Also fibrosis
Microscopic (histologic) images

Images hosted on other servers:

14 year old boy: images from pancreas, duodenum, lymph node

Stillborn fetus (34 weeks) with anencephaly and diabetic mother