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Herpes simplex pancreatitis

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 23 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Rare cause of acute pancreatitis; often coexists with HSV hepatitis (Eur J Gastroenterol Hepatol 2009;21:114)

Gross description

● Small, discrete foci of hemorrhagic necrosis

Micro description

● Parenchymal necrosis, hemorrhage, minimal fat necrosis, mild neutrophilic infiltrate compared to intensity of necrosis (Arch Pathol Lab Med 2003;127:231)
● Atrophic acinar cells
● Numerous eosinophilic intranuclear inclusions with clear halos (Cowdry type A), many multinucleated giant cells with hyperchromatic irregular nuclei and eosinophilic cytoplasm
● Some nuclei have basophilic, ground-glass/smudged appearance

Micro images

Various images

End of Pancreas > Pancreatitis > Herpes simplex pancreatitis

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